RETINYL PALMITATE (VITAMIN A)
The esters (palmitate and acetate) are used in beauty care.

Vitamin A (-palmitate, -acetate) is also called the «normalizing vitamin».

It displays the following properties

enhancement of mitotic activity
improvement of enzyme activity
normalization of keratinization
improvement of epithelization

Vitamin A Palmitate has attracted great interest in recent years since it is the active agent for the treatment of \aging skin in beauty care.

Vitamin A Palmitate promotes the enzyme activity in the skin, thickens the epidermis and can regenerate skin prematurely aged by UV-radiation.

Penetration investigations and studies of the action of Vitamin A Acetate on the skin have been published in recent years. The latest investigations show that good results have also been achieved with Vitamin A Palmitate this derivative is very much more stable in cosmetic formulations.

Table 1 shows the penetration data with labelled Vitamin A Palmitate.

The protocol of D.F. Counts et al. (USA 1988) is set out in Table 2.

When an emulsion containing Vitamin A Palmitate is topically applied, a significant 
increase in the thickness of the epidermis and a rise in the collagen content of the 
skin is observed.

An optimal dosage for a cosmetic product containing Vitamin A Palmitate of 0.5% 0.6% can be derived from Tables 3 and 4.

The positive effects of Vitamin A Palmitate on skin damaged by UV radiation in mice have been listed in an unpublished paper. As in previous studies, a thickening and normalization of the damaged epidermis was observed. Through the use of a cream with 10 000 IU/g Vitamin A- palmitate,the wrinkle index is reduced from approx. 2.5 to 1.7 (Vitamin A Palmitate) and to approx. 1.6 (Vitamin A-alcohol) (Fig. 1).

G. Klecak (1989) determined the change in the elasticity of the skin effected by Vitamin A Palmitate. The investigation was carried out with a dosage of 10 000 IU/g Vitamin A Palmitate over a period of 15 days and resulted in a significant change in the modulus of elasticity. In this manner, the elasticity of the skin this designates the resistance of the skin to deformation rose by 14% in comparison with the pretreatment condition, i.e., from 100 to 86. Supplementary investigations on the effect of Vitamin A Palmitate in various cosmetic formulations for intervals of 30, 60 and 90 days are currently being carried out (Fig. 2).

Vitamin A Palmitate

can regenerate skin damaged by UV radiation up to a certain degree after treatment with retinoic acid, nourishes skin damaged by UV radiation improves the natural skin functions especially suitable for care of aging skin.

The information given in this publication is based on our current knowledge and experience, and may be used at your discretion and risk. It does not relieve you from carrying out your own precautions and tests. We do not assume any liability in connection with your product or its use. You must comply with all applicable laws and regulations, and observe all third party rights.
   
   

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